Paper-based electrochemical (bio)sensors
The use of paper has opened to a new development towards the design of brand-new portable analytical devices. In particular, it has allowed to overcome some limitations of previous systems: the porosity of paper allows to actively operate within the analytical procedure by pre-treating the sample, loading reagents, making reactions happen and printing electrodes. The creation of all-in-one and sustainable devices acquires a stronger value being tools for society.
- Cinti, S.,* Moscone, D., & Arduini, F. (2019). Preparation of paper-based devices for reagentless electrochemical (bio) sensor strips. Nature protocols, 14(8), 2437-2451. (Read it)
- Cinti, S.,* Fiore, L., Massoud, R., Cortese, C., Moscone, D., Palleschi, G., & Arduini, F. (2018). Low-cost and reagent-free paper-based device to detect chloride ions in serum and sweat. Talanta, 179, 186-192. (Read it)
- Cinti, S., Talarico, D., Palleschi, G., Moscone, D., & Arduini, F. (2016). Novel reagentless paper-based screen-printed electrochemical sensor to detect phosphate. Analytica chimica acta, 919, 78-84. (Read it)
Nanoparticles and nanocomposites
The use of nanomaterials has highlighted obvious enhancement in the field of analytical science. Respect to their bulk counterparts, nanoparticles and nano composites have been showing great performances. Novel synthetic strategies, e.g. paper-based synthesis, and improved combinations between different sources of nanosized matters are capable to enhance sensitivity and reliability of detection architectures.
Bagheri, N., Mazzaracchio, V., Cinti, S.,* Colozza, N., Di Natale, C., Netti, P. A., Saraji, M., Roggero, S., Moscone, D., & Arduini, F. (2021). Electroanalytical Sensor Based on Gold-Nanoparticle-Decorated Paper for Sensitive Detection of Copper Ions in Sweat and Serum. Analytical Chemistry, 93, 5225–5233. (Read it)
- Bagheri, N., Cinti, S.,* Caratelli, V., Massoud, R., Saraji, M., Moscone, D., & Arduini, F. (2019). A 96-well wax printed Prussian Blue paper for the visual determination of cholinesterase activity in human serum. Biosensors and Bioelectronics, 134, 97-102. (Read it)
- Cinti, S., Colozza, N., Cacciotti, I., Moscone, D., Polomoshnov, M., Sowade, E., Baumann, R.R. & Arduini, F. (2018). Electroanalysis moves towards paper-based printed electronics: carbon black nanomodified inkjet-printed sensor for ascorbic acid detection as a case study. Sensors and Actuators B: Chemical, 265, 155-160. (Read it)
Liquid biopsy and healthcare
The detection of circulating cancer biomarkers, e.g ctDNA, miRNA, tumor cells, exosomes, also known as liquid biopsy, opens up a revolutionary opportunity in cancer detection and therapy monitoring and has been listed within the top 10 of global emerging technologies. The development of point of care devices for cancer research is gaining a lot of attention within the sensor community. The possibility to get rapid information in tiny amount of bodily fluids is the challenge.
- Cinti, S.,* Cinotti, G., Parolo, C., Nguyen, E. P., Caratelli, V., Moscone, D., Arduini, F. & Merkoçi, A. (2019). Experimental Comparison in Sensing Breast Cancer Mutations by Signal ON and Signal OFF Paper-Based Electroanalytical Strips. Analytical Chemistry, 92, 1674-1679. (Read it)
- Cinti, S.,* Proietti, E., Casotto, F., Moscone, D., & Arduini, F. (2018). Paper-based strips for the electrochemical detection of single and double stranded DNA. Analytical chemistry, 90(22), 13680-13686. (Read it)
- Cinti, S.,* De Lellis, B., Moscone, D., & Arduini, F. (2017). Sustainable monitoring of Zn (II) in biological fluids using office paper. Sensors and Actuators B: Chemical, 253, 1199-1206. (Read it)
The search of novel materials/scaffolds to be integrated in smart architectures for sensing devices represents a hot topic in analytical chemistry. To date, both optical and electrochemical methods have been combined with the most diverse (and un-common) materials: pins, origami, removable tattoos, film for packaging, office paper. All these examples highlight the suitability of certain materials, generally employed in different context, to be used for reaching “different” analytical answers.
- Cinti, S.,* Marrone, R., Mazzaracchio, V., Moscone, D., & Arduini, F. (2020). Novel bio-lab-on-a-tip for electrochemical glucose sensing in commercial beverages. Biosensors and Bioelectronics, 165, 112334. (Read it)
- Cinti, S.,* Mazzaracchio, V., Öztürk, G., Moscone, D., & Arduini, F. (2018). A lab-on-a-tip approach to make electroanalysis user-friendly and de-centralized: Detection of copper ions in river water. Analytica chimica acta, 1029, 1-7. (Read it)
- Cinti, S.,* Basso, M., Moscone, D., & Arduini, F. (2017). A paper-based nanomodified electrochemical biosensor for ethanol detection in beers. Analytica chimica acta, 960, 123-130. (Read it)
Sometimes, the routes to produce the optimal device might be time-consuming and costly. The role of chemometric-based tools is strategic in the conceptualization, production, and data analysis in developing reliable portable devices and also decrease the amount of experiments (thus, costs) at the same time.
- Tortorella, S., & Cinti, S*. (2021). How Can Chemometrics Support the Development of Point of Need Devices? Analytical Chemistry, 93, 5, 2713–2722. (Read it)